Biotransformation of whey by Weissella cibaria suppresses 3T3-L1 adipocyte differentiation

Biotransformation, the structural modification of chemical compounds, has proved to be an indispensable tool in providing beneficial health effects. Although benefits biotransformation using plant sources been widely studied, anti-adipogenic effect biotransformed dairy products, such as whey, have not yet demonstrated. Here, we investigated whey by Weissella cibaria 3T3-L1 adipocytes. cibaria-biotransformed considerably reduced accumulation lipid droplets and intracellular triglycerides cells. In presence W. mRNA protein expression a key transcription factor, peroxisome proliferator-activated receptor γ (PPARγ), for adipogenesis was markedly suppressed Additionally, also decreased expressions lipoprotein lipase adipocyte fatty acid-binding protein, which are regulated PPARγ. Moreover, inhibited adipokines, resistin, leptin. Collectively, these results suggest that potential exert effects inhibiting signaling events adipogenic-related factors target genes.